Loss of Nrf2 Signaling with ER Stress: "We have explained that several factors can lead to impairment of Nrf2 including nutrition, actions of other proteins that interact with it, genetic factors, aging, endoplasmic reticulum stress, etc. On the other hand, ER stress is characterized by the accumulation of misfolded proteins, altered Ca2+ regulation and up-regulations of other proteins including GRP78. Consistent activation of TRPV1,"
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