The Mechanisms of Heavy Metal Cytotoxicity!: "Different metals have different mechanisms for toxicity. In flies, DAF-16, the homolog of the FOXO family in humans, can be effected by exposure to different metals which activate cell signaling pathways to achieve it. Copper is an insulin mimetic and long-term exposure may result in insulin resistance and it inhibits the G-6-P promoter which is important in the healthy maintenance of"
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