Nitrosamines and PGC-1a: "PGC-1a is an important component for the detoxification of nitrosamines. Excess levels can lead to enhanced toxicity. A recent study shows nitrosamine increases oxidative and nitrosative stress and elevates inflammatory mediators including Tnf-a , MCP-1 and Il-1 by activation of microglia and astrocytes resulting in neuronal damage. Nitrosamines are chemical compounds which are produced from"
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