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Wednesday, November 4, 2009

liver fibrosis, dendritic cells govern hepatic inflammation in mice via tnf-α

Title: In liver fibrosis, dendritic cells govern hepatic inflammation in mice via tnf-α

Summary: "After liver injury, DCs gained a marked capacity to induce hepatic stellate cells, NK cells, and T cells to mediate inflammation, proliferation, and production of potent immune responses. The proinflammatory and immunogenic effects of fibrotic DCs were contingent on their production of TNF-α."

Connolly, M. K., Bedrosian, A. S., Mallen-St, J., Mitchell, A. P., Ibrahim, J., Stroud, A., Pachter, H. L., Bar-Sagi, D., Frey, A. B., and Miller, G. (2009). In liver fibrosis, dendritic cells govern hepatic inflammation in mice via tnf-α. The Journal of Clinical Investigation, 119(11):3213-3225

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