Alterations in genes occur in Western diet participants compared to controls. Most of these genes were related to metabolic processes such as lipid metabolism and glutathione metabolism, which is important for preventing damage caused by oxidation. In addition, expression of a series of genes collectively associated with immune and inflammatory responses was altered. The Western diet also increased the number of macrophages, cells associated with inflammation in the colon, as well as several proteins such as myeloperoxidase and MCP-1 and colonic oxidative stress genes associated with inflammation.
Source:High fat diet increases inflammation in the mouse colon
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