Toxic Coeliac Disease Protein Drives Inflammation By Down-Regulating PPAR-gamma

Gliadin is a toxic protein implicated as a factor in coeliac disease that cause activation of the innate immune response. The protein unregulates tissue enzymes that cause inflammation and down-regulate the anti-inflammatory PPAR-gamma


CiteULike: Lysosomal accumulation of gliadin p31–43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARγ downregulation in intestinal epithelial cells and coeliac mucosa: "Maiuri, L., Luciani, A., Villella, V. R., Vasaturo, A., Giardino, I., Pettoello-Mantovani, M., Guido, S., Cexus, O. N., Peake, N., Londei, M., and Quaratino, S. (2010). Lysosomal accumulation of gliadin p31–43 peptide induces oxidative stress and tissue transglutaminase-mediated pparγ downregulation in intestinal epithelial cells and coeliac mucosa. Gut, 59(3):311-319."